Wednesday, August 6, 2014

Higher vitamin D levels increase survival rate in postoperative adults with colorectal cancer


Colorectal cancer is a huge problem for North American men so ladies here is some encouraging news to help increase the chances of you man sticking around longer. Thanks to Usana Health Sciences Inc for this weekly update on The Essentials of Health.
Higher vitamin D levels increase survival rate in postoperative adults with colorectal cancer
August 06, 2014
   Higher vitamin D levels increase survival rate in postoperative adults with colorectal cancer

At a Glance
A new research article published online suggests that having a higher plasma level of vitamin D is associated with a better chance of surviving colorectal cancer.

Read more about this research below. 
 Low vitamin D levels are known to be associated with poor health outcomes or increased risk in many diseases including cardiovascular disease, diabetes, and some cancers.   

In a new study published in the Journal of Oncology, researchers investigated whether the plasma level of vitamin D after a diagnosis of colorectal cancer (CRC) has a significant impact on survival outcome.  The Scottish research team analyzed data from 1,598 adults who had undergone surgery for stage I-III colorectal cancer.  Blood samples were taken after surgery and evaluated for vitamin D and for a specific Vitamin D gene receptor.

When compared to the patients with the lowest one-third of vitamin D levels, the patients whose vitamin D levels were in the top one-third of subjects had a significantly lower (32%) risk of dying of CRC and a 30% lower risk of dying from any cause during the 5 year follow-up period.  In patients with stage II CRC, those in the top one-third of vitamin D levels experienced a 56% reduction in mortality. 
The researchers found interactions between vitamin D levels and specific type of vitamin D gene receptor, indicating a causal relationship between vitamin D and survival.  
This study shows that in patients with stage I-III colorectal cancer, higher post-surgery vitamin D levels are associated with a better outcome and a lower risk of mortality.  Since this was an observational study, carefully designed clinical trials are still needed to confirm whether vitamin D supplementation would provide survival benefits for patients with colorectal cancer. 

Zgaga L Plasma Vitamin D Concentration Influences Survival Outcome After a Diagnosis of Colorectal Cancer.  J Clin Oncol. 2014 Jul 7. pii: JCO.2013.54.5947. [Epub ahead of print]
 

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