March 25, 2015
Probiotics reduce the incidence of diarrhea during antibiotic therapy
At a Glance
According to a meta-analysis of 63 studies, taking probiotics significantly reduces the risk of developing diarrhea that often results from the use of antibiotics.
Read more about this research below.
In a large meta-analysis published in the Journal of the American Medical Association, researchers pooled data from 63 different randomized clinical trials to determine the usefulness of probiotics in the “prevention and treatment of antibiotic-associated diarrhea.” The trials involved 11,811 participants, the majority of which were outpatients, but some of those included were hospitalized patients. The majority of the trials used a Lactobacillus based strain; the other strains included Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, and/or Bacillus. Analysis of all the included data revealed that those taking probiotics had on average a 42% lower risk of developing diarrhea than those in the control groups.
The results of this meta-analysis support the idea that concurrent use of probiotics during antibiotic therapy may help maintain gut flora balance and reduce the incidence of side effects such as diarrhea.
Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA : the journal of the American Medical Association. 2012;307(18):1959-69.